Distinct pattern of rheumatoid factor serotypes in serial evaluation of patients with early rheumatoid arthritis
نویسندگان
چکیده
In the last decades, there has been a significant evolution in the knowledge of rheumatoid arthritis (RA) physiopathogeny, leading to changes in disease’s approach and therapeutics. The concept of “early or initial rheumatoid arthritis” was defined by the majority of authors as the initial phase of disease symptoms up to 12 months, period of time in which Distinct pattern of rheumatoid factor serotypes in serial evaluation of patients with early rheumatoid arthritis
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Differential Expression of Rheumatoid Factor-Associated Cross-Reactive Idiotypes in Iranian Seropositive and Seronegative Patients with Rheumatoid Arthritis
High levels of rheumatoid factors (RF) are detectable in serum of the majority of patients with rheumatoid arthritis (RA), but 5-10% of patients remain seronegative (SN). Despite clinical and genetic similarities between these two subsets of RA, it has been proposed that they may be regarded as distinct clinical entities. Methods: In the present study a panel of monoclonal antibodies (mAb) rec...
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